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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK1
All Species:
46.36
Human Site:
S281
Identified Species:
78.46
UniProt:
Q13153
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13153
NP_001122092.1
545
60647
S281
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Chimpanzee
Pan troglodytes
XP_508657
536
59744
S281
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Rhesus Macaque
Macaca mulatta
XP_001090077
545
60664
S281
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Dog
Lupus familis
XP_849651
544
60649
S280
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Cat
Felis silvestris
Mouse
Mus musculus
O88643
545
60718
S281
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Rat
Rattus norvegicus
P35465
544
60559
S280
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509462
527
58159
K281
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
Chicken
Gallus gallus
NP_001155844
544
60631
S280
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
Frog
Xenopus laevis
NP_001079232
564
62749
S299
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
I
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
M280
D
K
S
R
K
K
K
M
S
D
E
E
I
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
T379
N
K
I
G
E
G
S
T
G
T
V
C
I
A
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
S306
D
K
I
G
S
G
A
S
G
S
V
Y
T
A
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
S631
V
K
I
G
Q
G
A
S
G
G
V
Y
T
A
Y
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
S685
T
K
I
G
Q
G
A
S
G
G
V
Y
T
G
H
Conservation
Percent
Protein Identity:
100
94.3
99.6
96.6
N.A.
97.6
98.9
N.A.
78.7
94.5
80.6
81.9
N.A.
32.7
N.A.
54.7
N.A.
Protein Similarity:
100
95.2
99.6
97
N.A.
98.7
99
N.A.
85.3
96.8
88.3
87.8
N.A.
50.8
N.A.
68.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
100
93.3
6.6
N.A.
53.3
N.A.
73.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
100
100
20
N.A.
73.3
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.5
32.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.6
43.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
80
73.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
79
0
0
0
0
0
0
79
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
15
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
58
0
0
8
8
0
0
0
0
0
8
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
86
0
86
0
0
86
15
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
86
0
0
0
8
0
0
0
0
0
15
0
15
% I
% Lys:
0
93
0
0
8
8
8
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
50
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
72
0
0
0
8
0
0
0
8
8
8
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
8
0
8
79
8
8
0
0
0
0
0
% S
% Thr:
15
0
0
0
0
0
0
8
0
65
0
0
79
0
8
% T
% Val:
8
0
0
0
8
0
0
0
0
0
86
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
79
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _